one simply solution like below, you can also use the ucase(col) if not case sensitive.
create table t ( col1 varchar(30),col2 varchar(20))
select col1,col2,
iif(instr(col1,'A')>0,10)+iif(instr(col2,'A')>0,1) as flgA,
iif(instr(col1,'B')>0,10)+iif(instr(col2,'B')>0,1) as flgA...