Setting up links is pretty easy; just use the Link Table Wizard, Select ODBC Drivers, and then select the MySQL Database which you have set up drivers for. Someone else can probably give you more advice on upsizing; I do this configuration quite a bit with DB2 databases, but what I have to do is pull down large chunks of data and work with it locally, so my set-up is really not "upsized" (i.e. I'm not passing data back and forth, as you're probably going to be trying to do).