Create a new query, add the table add the fields you require, change the query to an update by selecting the option from the drop down list on the menu bar, on the update to line put 0, on the criteria line put Is Null ,try it on a copy of your table first.
SQL will look something like UPDATE TableName SET TableName.SomeField = 0 WHERE ((TablName.SomeField) Is Null);
HTH