Switch your form to Design view, select Combo1, display the Properties window, select the Event tab, click in the white space to the right of After Update, then click the little button with the three dots that appears at the end of the white space. A Choose Builder dialog box will appear. Select Code Builder and click OK. The form's code module window will open, and you'll see a procedure stub that looks like this:
Private Sub Combo1_AfterUpdate()
End Sub
Between these two statements you must add the appropriate code, which will vary depending on the possible values in Combo1's bound column and the corresponding RowSource values for Combo 2. Here's an example:
Select Case Combo1
Case 1: Combo2.RowSource = "Query1"
Case 2: Combo2.RowSource = "Query2"
Case Else: Combo2.RowSource = "QueryDefault"
End Select