Probably doing your work for you:
I am guessing you want a button to run an update query using the "item" field in both tables. The SQL query would be something like (auto-generated after I used the GUI):
UPDATE log INNER JOIN setup ON log.item = setup.item
SET log.amount = Log.amount-setup.amount;
If using the GUI, create a new query - set it to an update query - display both the log and setup tables -creat the join on the "item" which I assume is the primary key - then under the "Update To:" row enter (Under the log field):Log.amount-setup.amount
Hopefully that will work.