I consider myself an optimist too, in cases where optimism is capable of working.
Some things we might hope for (faster-than-light travel, for example) aren't really worth hoping for outside of science fiction, because they're already explicitly ruled out by very fundamental laws of physics, etc.
That's not to say the laws of physics couldnt be overturned by some new and huge discovery, but such a thing is really quite unlikely - it would mean that we have to find brand new, and different, explanations for how and why everything works - including stuff like the transisitors and diodes in the computer on which you're reading this.
Engineers and scientists were able to design the electronic components in your PC based on their understanding of physics, if physics is rewritten, we have to work out:
a) How the transistors really work
b) Why we were able to make predictions about how they should work, based on incorrect physics.
It's possible, but really unlikely.
Some things are still unknown, however, and learning or discovering them will only supplement, not overturn our science.