Yes.
The users must open the secured db with a custom shortcut that provides the target info as to where the msaccess.exe file is located, where the workgroup file is located and where the db file is located. Here is a sample as to how the target field of your shortcut should look...
"C:\Program Files\Microsoft Office\OFFICE11\MSACCESS.EXE" /runtime /wrkgrp "X:\YourWorkgroupFile.mdw" "Z:\YouDatabaseFile.mdb" /user YourUserName
That is all on one line with a single space between each section.
Search the Access help files for more "Command Line Options".