you should be able to. Connection over VPN can be slow, particularly if your db has not been optimised for working on remote servers. Make sure your VPN is configured to provide sufficient bandwidth.
Best thing to do is try it - when at home, a) can you see the backend? if so b) note the path c) if necessary, use the linked table manager to reconnect your front end to the backend d) see how it performs.
Note Access does not take kindly to wireless connections (even a disconnection of a nano second can upset things) so make sure at home your computer is wired to your router.
A better solution would be to use terminal server or citrix. (Terminal server typically costs around 25$/user/month). Better because a) users have their own profile so you can mount the front ends in their user space and backend in shared space on the server so if you lose connection Access is not affected (and you can connect wirelessly if you have to) and b) performance will probably be better than your current setup - it will be like users have a local copy of the backend. You can also put all your shared files there as well - so someone does not have to go to the office if your office machine closes down for some reason. Also pretty easy to setup - simply copy your files across and relink the back ends. Given these extraordinary times it is probably a worthwhile investment.