Get rid of the cat?
Seriously, does the time-honored "wiggle the mouse all over the place until I see it on screen" method help? My first thought is that if you have one of those advanced desktop control apps, the mouse might have disappeared in the gap between the virtual edge of the screen and the physical edge of the screen.
I would suggest checking for a running timer, but you are experienced enough to know about timer effects on mice.
Are you on Win10 or something older? Does it disappear on apps other than Access?